Catalog No.: PC-24347Not For Human Use, Lab Use Only.
Trimetazidine is a potent, selective long chain 3-ketoyl coenzyme A thiolase inhibitor with IC50 of 75 nM, inhibit β-oxidation of free fatty acid (FFA).
Trimetazidine is a potent, selective long chain 3-ketoyl coenzyme A thiolase (LC 3-KAT) inhibitor with IC50 of 75 nM, inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine also triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
Physicochemical Properties
M.Wt
266.34
Formula
C14H22N2O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(2,3,4-trimethoxybenzyl)piperazine
References
1. Hossain F, et al. Cancer Immunol Res. 2015 Nov;3(11):1236-47.
2. Shenghu He, et al. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4.
3. Kantor PF, et al. Circ Res. 2000 Mar 17;86(5):580-8.
