Triptolide |CAS:38748-32-2 Probechem Biochemicals

Chemical Structure : Triptolide

CAS No.: 38748-32-2

Triptolide (PG490;PG 490;PG-490)

Catalog No.: PC-45814Not For Human Use, Lab Use Only.

Triptolide (PG490) is the active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$188	In stock
25 mg	$298	In stock
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Biological Activity

Triptolide (PG490) is the active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.
Triptolide (PG490) arrests cellular proliferation and attenuates overall cyst formation by restoring Ca(2+) signaling in a murine model of ADPKD.
Triptolide (PG490) also covalently binds to human XPB (ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription.
Triptolide (PG490) inhibits TAK1 kinase activity by interfering with the formation of the TAK1-TAB1 complex in macrophages.

Physicochemical Properties

M.Wt	360.401
Formula	C20H24O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

References

1. Leuenroth SJ, et al. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4389-94.

2. Titov DV, et al. Nat Chem Biol. 2011 Mar;7(3):182-8.

3. Lu Y, et al. Chem Biol. 2014 Feb 20;21(2):246-56.

Triptolide (PG490;PG 490;PG-490)

Biological Activity

Physicochemical Properties

References

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