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TrkA agonist D3

Chemical Structure : TrkA agonist D3

CAS No.: 256470-85-6

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TrkA agonist D3

Catalog No.: PC-28388Not For Human Use, Lab Use Only.

TrkA agonist D3 is a small molecule NGF peptidomimetic ligand / agonist of TrkA receptor, induces TrkA tyrosine phosphorylation, stabilizes TrkA-TrkA homodimers, enhances ChAT production/activity, and induces neurotrophic activities in PC12 cells and primary neuronal cultures.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TrkA agonist D3 is a small molecule NGF peptidomimetic ligand / agonist of TrkA receptor, induces TrkA tyrosine phosphorylation, stabilizes TrkA-TrkA homodimers, enhances ChAT production/activity, and induces neurotrophic activities in PC12 cells and primary neuronal cultures.

Physicochemical Properties

M.Wt 579.57
Formula C24H33N7O10
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C1C=2C(=CC=C(N(=O)=O)C2)OCC[C@@H](C(NCC(N)=O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)N1

References

1. Maliartchouk S, et al. J Mol Pharmacol 57: 385-391.

2. Bruno M. A., et al. J. Neurosci. 24, 8009–8018 (2004).

3. Aboulkassim T., et al. Mol. Pharmacol. 80, 498–508 (2011).

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