Chemical Structure : TrkB agonist R13
CAS No.:
1609067-49-3
TrkB agonist R13
Catalog No.: PC-20760Not For Human Use, Lab Use Only.
TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation.
R13 releases 7,8-DHF after absorption and significantly increases its oral bioavailability.
Oral administration of R13 elicits robust TrkB receptor activation in the brain and the gut and inhibits AEP via Akt-mediated T322 phosphorylation.
R13 not only represses AEP expression through blunting its upstream transcription factor C/EBPβ but also blocks AEP activation via BDNF/TrkB pathway-activated Akt.
R13 treatment significantly elevates OPG in both mice without altering RANKL, blocking trabecular bone loss in vivo.
Physicochemical Properties
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M.Wt
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368.35
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Formula
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C19H16N2O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C1C2=CC=C(OC(NC)=O)C(OC(NC)=O)=C2OC(C3=CC=CC=C3)=C1
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References
1. Jing Xiong, et al. Nat Commun. 2022 Aug 16;13(1):4820.
2. Chun Chen, et al. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):578-583.
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