TrkC.T1 antagonist CP14 | TrkC.T1 inhibitor

Chemical Structure : TrkC.T1 antagonist CP14

TrkC.T1 antagonist CP14 (Cyclic-14-KI)

Catalog No.: PC-24089Not For Human Use, Lab Use Only.

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Biological Activity

Cyclic-14-KI (CP14) is a specific, noncompetitive and allosteric antagonist of TrkC truncated isoform TrkC.T1, selectively antagonize TrkC, reduces CP14 reduces the affinity of NT3 binds to TrkC.T1 with Kd of 11.5 nM.
Cyclic-14-KI (CP14) does not inhibit TrkC-FL/NT3 and does not affect the binding of PTPs to either isoform.
Cyclic-14-KI (CP14) blocks up-regulation of TNF-α mRNA, does not have any effect on receptor family members TrkA or TrkB that are activated by their respective ligands NGF or BDNF.
Cyclic-14-KI (CP14) decreases TNF-α protein and cell death in retinal explants of RHOP347S mice.
Cyclic-14-KI (CP14) decrease photoreceptor cell death in the RHOP347S mice retina in vivo.

Physicochemical Properties

M.Wt	489.57
Formula	C24H35N5O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(10-(4-aminobutyl)-7-(sec-butyl)-3,6,9,12-tetraoxo-1,2,3,4,5,6,7,8,9,10,11,12-dodecahydrobenzo[l][1,4,7,10]tetraazacyclotetradecin-4-yl)acetic acid

References

1. Brahimi F, et al. PNAS Nexus. 2025 Feb 4;4(2):pgaf020.

TrkC.T1 antagonist CP14 (Cyclic-14-KI)

Biological Activity

Physicochemical Properties

References

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