TrmD-IN-1

Chemical Structure : TrmD-IN-1

Catalog No.: PC-27822Not For Human Use, Lab Use Only.

TrmD-IN-1 (Compound 8h) is a specific small molecule inhibitor of S. aureus tRNA (m1G37) methyltransferase (TrmD) with KD of 2.48 uM in FP-assays, does not affect Trm5, shows antimicrobial effects at low micromolar concentrations.

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Biological Activity

Physicochemical Properties

M.Wt	287.29
Formula	C11H13N9O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(4-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-1,2,3-triazol-1-yl)ethyl)guanidine

References

1. Hübner AF, et al. J Med Chem. 2025 Dec 25;68(24):26246-26262.

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TrmD-IN-1

Biological Activity

Physicochemical Properties

References

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