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Chemical Structure : Tubacin
CAS No.: 537049-40-4
Catalog No.: PC-43533Not For Human Use, Lab Use Only.
Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM, displays> 300-fold selectivity against all other HDAC isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $578 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM, displays> 300-fold selectivity against all other HDAC isoforms.
Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures, inhibits proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.
Tubacin also suppresses proliferation and induces apoptosis of AML cells.
| M.Wt | 721.861 | |
| Formula | C41H43N3O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Octanediamide, N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-, rel- |
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1. Haggarty SJ, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94.
2. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
3. Saji S, et al. Oncogene. 2005 Jun 30;24(28):4531-9.
4. Rao R, et al. Blood. 2008 Sep 1;112(5):1886-93.
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