Tubulin inhibitor No.07

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Chemical Structure : Tubulin inhibitor No.07

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Catalog No.: PC-24416Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Tubulin inhibitor No.07 is a novel tubulin inhibitor, irectly binds to tubulin dimers and interferes with microtubule polymerization, shows anti-cancer and anti-metastatic effects in colon cancer and tumoroids (Hela cell IC50=455 nM).
No.07 increases cellular ROS and inactivates the RAF-MEK-ERK signaling axis, reducing metastasis.
No.07 overcomes multidrug resistance, improving the effectiveness of existing chemotherapy.

Physicochemical Properties

M.Wt	316.72
Formula	C16H10ClFN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-chlorophenyl)-N-(6-fluoropyridin-3-yl)furan-2-carboxamide

References

1. Han HJ, et al. Life Sci. 2025 Apr 17:123644. doi: 10.1016/j.lfs.2025.123644.

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