Tucidinostat (Chidamide, HBI-8000, CS055)| HDAC inhibitor

Chemical Structure : Tucidinostat

CAS No.: 1616493-44-7

Tucidinostat (Chidamide, HBI-8000, CS-055)

Catalog No.: PC-35344Not For Human Use, Lab Use Only.

Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$198	In stock
100 mg		Get quote

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Biological Activity

Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively.
Tucidinostat (HBI-8000) shows no activity against Class IIa HDAC4/4/7/9 and HDAC6.
Tucidinostat (HBI-8000) demonstrates significant and broad spectrum in vitro and in vivo antitumor activity, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

Physicochemical Properties

M.Wt	390.418
Formula	C22H19FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide

References

1. Ning ZQ, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9.

2. Gong K, et al. Biochem J. 2012 May 1;443(3):735-46.

3. Dong M, et al. Cancer Chemother Pharmacol. 2012 Jun;69(6):1413-22.

4. Gao S, et al. Anticancer Agents Med Chem. 2017;17(6):802-812.