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Tulrampator

Chemical Structure : Tulrampator

CAS No.: 1038984-31-4

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Tulrampator (S 47445;CX 1632)

Catalog No.: PC-61726Not For Human Use, Lab Use Only.

Tulrampator (S 47445, CX 1632) is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 2.5-5.4 uM for different AMPA receptors subtypes (GluA1/2/4 flip and flop variants).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tulrampator (S 47445, CX 1632) is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 2.5-5.4 uM for different AMPA receptors subtypes (GluA1/2/4 flip and flop variants).
Tulrampator exhibits procognitive and potential neuroprotective properties in vivo.

Physicochemical Properties

M.Wt 380.379
Formula C20H17FN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione

References

1. Calabrese F, et al. Pharmacol Res. 2017 Jul;121:59-69.

2. Giralt A, et al. Neuropharmacology. 2017 Sep 1;123:395-409.

3. Bretin S, et al. PLoS One. 2017 Sep 8;12(9):e0184429.

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