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Chemical Structure : Tuvusertib
CAS No.: 1613200-51-3
Catalog No.: PC-21858Not For Human Use, Lab Use Only.
Tuvusertib (M1774) is a potent, selective, orally bioavailable ATR protein kinase inhibitor, shows anticancer activity against cance cell with expression the ATR inhibition sensitizing mixed lineage leukemia fusion protein.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 100 mg | Get quote |
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Tuvusertib (M1774) is a potent, selective, orally bioavailable ATR protein kinase inhibitor, shows anticancer activity against cance cell with expression the ATR inhibition sensitizing mixed lineage leukemia fusion protein.
Tuvusertib (M1774) shows antitumor activity as monotherapy in preclinical models with DDR pathway gene mutations, including an ATM mut nonsmall-cell lung cancer (NSCLC) xenograft model and an ARID1A mut gastric cancer xenograft model.
Tuvusertib (M1774) also shows antitumor activity as monotherapy and in combination with the PARP inhibitor niraparib in xenograft models of BRCA mut high-grade serous ovarian cancer.
| M.Wt | 370.32 | |
| Formula | C16H12F2N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Amino-6-fluoro-N-[5-fluoro-4-(1-methyl-1H-imidazol-5-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide |
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1. Timothy A. Yap, et al. Journal of Clinical Oncology
Volume 39, Number 15_suppl. May 28, 2021
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