Catalog No.: PC-45785Not For Human Use, Lab Use Only.
Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC.
Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC.
Tyrphostin AG 879 is 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
Tyrphostin AG 879 inhibits growth of FET6αS26X cells in a concentration-dependent manner.
Tyrphostin AG 879 blocks the activation of PAK1 and suppresses RAS-induced malignant transformation of NIH 3T3 cells.
Tyrphostin AG 879 reduces the size of the growing sarcomas in the nude mice carrying v-Ha-RAS transformed NIH 3T3 cells.
