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Chemical Structure : U-46619
CAS No.: 56985-40-1
Catalog No.: PC-62041Not For Human Use, Lab Use Only.
U-46619 is a potent and stable thromboxane A2 (TP) receptor agonist with EC50 of 35 nM.
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U-46619 is a potent and stable thromboxane A2 (TP) receptor agonist with EC50 of 35 nM.
U-46619 activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors, and potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in vitro.
| M.Wt | 350.5 | |
| Formula | C21H34O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid |
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1. Miggin SM, et al. Mol Pharmacol. 2002 Apr;61(4):817-31.
2. Morinelli TA, et al. Am J Physiol. 1987 Nov;253(5 Pt 2):H1035-43.
3. Coleman RA, et al. Br J Pharmacol. 1981 Jul;73(3):773-8.
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