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Chemical Structure : U-73122
CAS No.: 112648-68-7
Catalog No.: PC-43523Not For Human Use, Lab Use Only.
U-73122 is an unselective phospholipase C (PLC) inhibitor, inhibits agonist-induced platelet aggregation with IC50 of 1-5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | Get quote |
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U-73122 is an unselective phospholipase C (PLC) inhibitor, inhibits agonist-induced platelet aggregation with IC50 of 1-5 uM.
U-73122 also inhibited PMN adherence to and transmigration through TNF-alpha-activated endothelium (IC50 <50 nM).
U-73122 inhibits PLC-dependent processes in human platelets and polymorphonuclear neutrophils.
U-73122 also directly modulates TRPM4 and TRPM3 channels, potentiates Ca(2) (+) -dependent TRPM4 currents in human Jurkat T-cells, endogenous TRPM4 in HEK293T cells and recombinant human TRPM4.
| M.Wt | 464.64 | |
| Formula | C29H40N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 4.8 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrole-2,5-dione, 1-[6-[[(17b)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]- |
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1. Bleasdale JE, et al. J Pharmacol Exp Ther. 1990 Nov;255(2):756-68.
2. Shi TJ, et al. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20004-8.
3. Smith RJ, et al. J Pharmacol Exp Ther. 1996 Jul;278(1):320-9.
4. Leitner MG, et al. Br J Pharmacol. 2016 Aug;173(16):2555-69.
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