UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor.
UAMC-2526 (50-100 uM) completely inhibits proliferation of HT-29 colorectal carcinoma cells.
UMAC-2526 inhibits autophagy in a colorectal cancer xenograft model and potentiates chemotherapy efficacy.
UMAC-256 inhibits autophagy in a healthy mouse model, animals treated with
compound UAMC-2526 showed lower levels of uncleaved (free) GFP, decreased LC3-II/LC3-I ratios and a marked increase of SQSTM1.
UAMC-2526 combined with gemcitabine significantly reduced tumor growth as compared to the individual treatments, did not inhibit autophagy in the Panc02 mouse model.
