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Chemical Structure : UAMC-2526
Catalog No.: PC-72136Not For Human Use, Lab Use Only.
UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor.
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UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor.
UAMC-2526 (50-100 uM) completely inhibits proliferation of HT-29 colorectal carcinoma cells.
UMAC-2526 inhibits autophagy in a colorectal cancer xenograft model and potentiates chemotherapy efficacy.
UMAC-256 inhibits autophagy in a healthy mouse model, animals treated with
compound UAMC-2526 showed lower levels of uncleaved (free) GFP, decreased LC3-II/LC3-I ratios and a marked increase of SQSTM1.
UAMC-2526 combined with gemcitabine significantly reduced tumor growth as compared to the individual treatments, did not inhibit autophagy in the Panc02 mouse model.
| M.Wt | 383.194 | |
| Formula | C16H15BrO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kurdi A, et al. Biochem Pharmacol. 2017 Aug 15;138:150-162.
2. Salado IG, et al. Eur J Med Chem. 2018 May 10;151:18-26.
3. Takhsha FS, et al. Front Oncol. 2021 Nov 18;11:750259.
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