You are here:Home-Chemical Inhibitors & Agonists-Antibiotics and Antivirals-Enterovirus-UAWJ172
UAWJ172

Chemical Structure : UAWJ172

CAS No.: 878922-36-2

UAWJ172 (UAWJ 172)

Catalog No.: PC-20016Not For Human Use, Lab Use Only.

UAWJ172 is a potent and broad-spectrum inhibitor against enterovirus with IC50 of 0.1-0.8 uM agianst EV-D68, EV-A71 and CVB3 strains, targets viral 2C protein.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UAWJ172 is a potent and broad-spectrum inhibitor against enterovirus with IC50 of 0.1-0.8 uM agianst EV-D68, EV-A71 and CVB3 strains, targets viral 2C protein.
    UAWJ172 inhibits plaque formation of EV-D68 US/MO/14-18947 with EC50 of 25 nM.
    UAWJ172 exhibits broad-spectrum antiviral activity against EV-D68, EV-A71, and CVB3.
    UAWJ172 inhibits different strains of EV-D68, EV-A71 and CVB3 with EC50 values in the nanomolar range and a cellular selectivity index of over 500.
    UAWJ172 inhibits viral replication in a dose-response manner in neuronal cell line SH-SY5Y with IC50 of 0.03 uM.
    UAWJ172 inhibits EV-D68 US/MO/14-18947 virus with an EC50 value of 0.07 ± 0.02 μM in CPE assay.

    Physicochemical Properties

    M.Wt 315.42
    Formula C17H25N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-cyclopropyl-N-(2-(dimethylamino)ethyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

    References

    1. Yanmei Hu, et al. J Med Chem. 2021 Jun 24;64(12):8755-8774.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: