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Chemical Structure : UBP 296
Catalog No.: PC-60772Not For Human Use, Lab Use Only.
UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM.
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UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM; displays 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors, little or no action at NMDA or group I mGlu receptors; blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.
| M.Wt | 333.3 | |
| Formula | C15H15N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dolman NP, et al. J Med Chem. 2005 Dec 1;48(24):7867-81.
2. More JC, et al. Neuropharmacology. 2004 Jul;47(1):46-64.
3. Andreou AP, et al. Br J Pharmacol. 2009 Jun;157(3):464-73.
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