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UBP 296

Chemical Structure : UBP 296

CAS No.: 745055-86-1

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UBP 296 (UBP296;UBP-296)

Catalog No.: PC-60772Not For Human Use, Lab Use Only.

UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM; displays 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors, little or no action at NMDA or group I mGlu receptors; blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.

Physicochemical Properties

M.Wt 333.3
Formula C15H15N3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

References

1. Dolman NP, et al. J Med Chem. 2005 Dec 1;48(24):7867-81.

2. More JC, et al. Neuropharmacology. 2004 Jul;47(1):46-64.

3. Andreou AP, et al. Br J Pharmacol. 2009 Jun;157(3):464-73.

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