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UBP296

Chemical Structure : UBP296

CAS No.: 745055-86-1

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UBP296 (UBP 296, UBP-296)

Catalog No.: PC-60772Not For Human Use, Lab Use Only.

UBP296 (UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UBP296 (UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM.
    UBP296 displays 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors, little or no action at NMDA or group I mGlu receptors.
    UBP296 blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.

    Physicochemical Properties

    M.Wt 333.3
    Formula C15H15N3O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

    References

    1. Dolman NP, et al. J Med Chem. 2005 Dec 1;48(24):7867-81.

    2. More JC, et al. Neuropharmacology. 2004 Jul;47(1):46-64.

    3. Andreou AP, et al. Br J Pharmacol. 2009 Jun;157(3):464-73.

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