UBP 302 (UBP-302) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM.
UBP 302 displays about 260-fold selectivity over AMPA receptors, 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors.
UBP 302 blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.
UBP 302 also protects against soman-induced seizures and neuronal degeneration in vivo.
