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Chemical Structure : UBP 302
Catalog No.: PC-60771Not For Human Use, Lab Use Only.
A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM.
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A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM; displays about 260-fold selectivity over AMPA receptors, 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors; blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers; also protects against soman-induced seizures and neuronal degeneration in vivo.
| M.Wt | 333.3 | |
| Formula | C15H15N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. More JC, et al. Neuropharmacology. 2004 Jul;47(1):46-64.
2. Mayer ML, et al. J Neurosci. 2006 Mar 15;26(11):2852-61.
3. Apland JP, et al. Neuroscience. 2009 Mar 3;159(1):380-9.
4. Andreou AP, et al. Br J Pharmacol. 2009 Jun;157(3):464-73.
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