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Chemical Structure : UBP684
Catalog No.: PC-49068Not For Human Use, Lab Use Only.
UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%.
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UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%.
UBP684 is use-independent pan-NMDA receptor allosteric potentiator.
UBP684 increases channel open probability and slows receptor deactivation.
UBP684 stabilizes the active form of the GluN2 ligand-binding domain.
| M.Wt | 256.345 | |
| Formula | C17H20O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sapkota K, et al. Neuropharmacology. 2017 Oct;125:64-79.
2. Chopra DA, et al. Sci Rep. 2017 Jul 31;7(1):6933.
3. Irvine MW, et al. Eur J Med Chem. 2019 Feb 15;164:471-498.
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