Catalog No.: PC-49068Not For Human Use, Lab Use Only.
UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%.
UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%.
UBP684 is use-independent pan-NMDA receptor allosteric potentiator.
UBP684 increases channel open probability and slows receptor deactivation.
UBP684 stabilizes the active form of the GluN2 ligand-binding domain.
Physicochemical Properties
M.Wt
256.345
Formula
C17H20O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-(4-methylpent-1-yl)-2-naphthoic acid
References
1. Sapkota K, et al. Neuropharmacology. 2017 Oct;125:64-79.
2. Chopra DA, et al. Sci Rep. 2017 Jul 31;7(1):6933.
3. Irvine MW, et al. Eur J Med Chem. 2019 Feb 15;164:471-498.
