Catalog No.: PC-49067Not For Human Use, Lab Use Only.
UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM.
UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM.
UBP792 inhibits NMDAR responses by reducing l-glutamate and glycine potencies and efficacies.
UBP792 inhibition is not competitive with the structurally-related positive allosteric modulator (PAM) UBP684.
UBP792 inhibition is pH-dependent, voltage-independent and use-independent.
UBP792 requires opening of the GluN2 ligand-binding domain for activity, but not that of the GluN1 subunit.
Physicochemical Properties
M.Wt
335.315
Formula
C19H13NO5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(E)-3-hydroxy-7-(2-nitrostyryl)-2-naphthoic acid
References
1. Sapkota K, et al. Neuropharmacology. 2021 Dec 15;201:108818.
