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Chemical Structure : UBP792
Catalog No.: PC-49067Not For Human Use, Lab Use Only.
UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM.
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UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM.
UBP792 inhibits NMDAR responses by reducing l-glutamate and glycine potencies and efficacies.
UBP792 inhibition is not competitive with the structurally-related positive allosteric modulator (PAM) UBP684.
UBP792 inhibition is pH-dependent, voltage-independent and use-independent.
UBP792 requires opening of the GluN2 ligand-binding domain for activity, but not that of the GluN1 subunit.
| M.Wt | 335.315 | |
| Formula | C19H13NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sapkota K, et al. Neuropharmacology. 2021 Dec 15;201:108818.
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