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Chemical Structure : UBX-390
Catalog No.: PC-22553Not For Human Use, Lab Use Only.
UBX-390 is a potent, selective cereblon (CRBN)-based androgen receptor (AR) degrader with DC50 of 2.41 nM in VCaP cells.
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UBX-390 is a potent, selective cereblon (CRBN)-based androgen receptor (AR) degrader with DC50 of 2.41 nM in VCaP cells.
UBX-390 degrades AR via proteasomal action in a prostate cancer cell line.
UBX-390 selectively degraded AR while sparing the degradation of other related nuclear receptors. UBX-390 exerted a more potent suppressive effect on mTOR pathway genes compared to ARV-110.
UBX-390 (10 mg/kg) exhibits therapeutic activity in xenograft models of prostate cancer.
UBX-390 shows broad activity against therapy-resistant AR mutations in the ligand-binding domain, has a stronger anti-proliferative effect than ARV-110 in VCaP, LNCaP cells (T878A mutation, no splice variant) and 22Rv1 (H875Y mutation, expresses AR variants such as AR-V7, ARV-12, and AR-V1).
| M.Wt | 909.03 | |
| Formula | C48H55F3N10O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee S, et al. Adv Sci (Weinh). 2024 Jul 3:e2400398.
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