Catalog No.: PC-43254Not For Human Use, Lab Use Only.
UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.
UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.
UC-112 also potently inhibits the growth of P-gp-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at 1 uM.
UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo.
