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Chemical Structure : UC-514321
CAS No.: 299420-83-0
Catalog No.: PC-62519Not For Human Use, Lab Use Only.
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $248 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | $858 | In stock | |
| 500 mg | Get quote |
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UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
UC-514321 shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
| M.Wt | 441.568 | |
| Formula | C26H35NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol |
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1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
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