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Chemical Structure : UCB-9260
CAS No.: 1515888-53-5
Catalog No.: PC-73214Not For Human Use, Lab Use Only.
UCB-9260 is a specific, orally active compound, inhibits tumour necrosis factor (TNF) signaling by stabilising an asymmetric form of the trimer, binds to TNF with Kd of 13 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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UCB-9260 is a specific, orally active compound, inhibits tumour necrosis factor (TNF) signaling by stabilising an asymmetric form of the trimer, binds to TNF with Kd of 13 nM.
UCB-9260 is selective for TNF over other superfamily members.
UCB-9260 inhibited TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM, and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.
UCB-9260 inhibited NF-κB with a geometric mean IC50 of 202 nM after TNF stimulation in HEK 293 cell-line.
UCB-9260 inhibited TNF-driven functional effects in vivo, showed a significant reduction of the clinical score in LPS challenged collagen antibody induced arthritis (CAIA) model.
| M.Wt | 423.51 | |
| Formula | C26H25N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1-(2,5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol |
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1. Daniel J Lightwood, et al. Nat Commun. 2021 Jan 25;12(1):583.
2. James O'Connell, et al. Nat Commun. 2019 Dec 19;10(1):5795.
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