UCP1173

Chemical Structure : UCP1173

Catalog No.: PC-27160Not For Human Use, Lab Use Only.

UCP1173 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 14 nM, 190 nM, 270 nM and 91 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, potent activity against MRSA strains possessing dfrA with MIC values of 1.25 and 2.5 ug/mL.

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Biological Activity

Physicochemical Properties

M.Wt	416.48
Formula	C24H24N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

References

1. Reeve SM, et al. Cell Chem Biol. 2016;23(12):1458-1467.

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UCP1173

Biological Activity

Physicochemical Properties

References

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