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Chemical Structure : UE2343
Catalog No.: PC-60371Not For Human Use, Lab Use Only.
UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.
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UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.
UE2343 (UE-2343, Xanamem) displays a superior preclinical profile for further development, and shows potential for cognitive impairment in early Alzheimer's disease (AD).
| M.Wt | 381.454 | |
| Formula | C19H19N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Webster SP, et al. Br J Pharmacol. 2017 Mar;174(5):396-408.
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