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UK-369003

Chemical Structure : UK-369003

CAS No.: 334827-98-4

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UK-369003 (Gisadenafil besylate, UK369003)

Catalog No.: PC-61897Not For Human Use, Lab Use Only.

UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6.
    UK-369003 demonstrates efficacy in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).

    Physicochemical Properties

    M.Wt 677.79
    Formula C23H33N7O5S.C6H6O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate

    References

    1. Rawson DJ, et al. Bioorg Med Chem. 2012 Jan 1;20(1):498-509.

    2. Martínez-Salamanca JI, et al. Eur Urol. 2011 Sep;60(3):527-35.

    3. Watson KJ, et al. Drug Metab Dispos. 2011 Jul;39(7):1203-13.

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