UK-414495 |CAS:337962-93-3 Probechem Biochemicals

Chemical Structure : UK-414495

UK-414495 (UK414495)

Catalog No.: PC-70064Not For Human Use, Lab Use Only.

A potent and selective inhibitor of neutral endopeptidase (NEP) with IC50 of 18.9 nM for hNEP.

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Biological Activity

A potent and selective inhibitor of neutral endopeptidase (NEP) with IC50 of 18.9 nM for hNEP; dose-dependently potentiates pelvic nerve-stimulated increases in VBF (EC50=37 nM); increases the amplitude and duration of VIP-induced increases in VBF in the anaesthetized rabbit.

Physicochemical Properties

M.Wt	339.453
Formula	C16H25N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[1-[[(5-Ethyl-1,3,4-thiadiazol-2-yl)amino]carbonyl]cyclopentyl]methyl]pentanoic acid

References

1. Pryde DC, et al. J Med Chem. 2006 Jul 13;49(14):4409-24.

2. Wayman CP, et al. Br J Pharmacol. 2010 May;160(1):51-9.

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UK-414495 (UK414495)

Biological Activity

Physicochemical Properties

References

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