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Chemical Structure : UK122
Catalog No.: PC-20179Not For Human Use, Lab Use Only.
UK122 (UK-122) is potent, selective inhibitor of urokinase-type plasminogen activator (uPA) with IC50 0.2 uM in cell-free indirect uPA assays.
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UK122 (UK-122) is potent, selective inhibitor of urokinase-type plasminogen activator (uPA) with IC50 0.2 uM in cell-free indirect uPA assays.
UK122 shows no or little inhibition of other serine proteases such as thrombin, trypsin, plasmin, and the tissue-type plasminogen activator (IC50 values >100 uM).
UK122 (100 uM) significantly suppresses the cell migration on fibronectin-coated slides by 80% on pancreatic cancer cells CFPAC-1 cell migration, does not inhibit cancer cell growth.
| M.Wt | 291.31 | |
| Formula | C17H13N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhu M, et al. Mol Cancer Ther. 2007 Apr;6(4):1348-56.
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