UKH-1114 (UKH1114) | S2R/TMEM97 agonist

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Chemical Structure : UKH-1114

UKH-1114 (UKH 1114, UKH1114)

Catalog No.: PC-61104Not For Human Use, Lab Use Only.

UKH-1114 (UKH1114) is a potent, sigma 2 receptor/Tmem97 agonist with Ki of 46 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UKH-1114 (UKH1114) is a potent, selective sigma 2 receptor/Tmem97 agonist with Ki of 46 nM.
UKH-1114 displays high selectivity for σ2R/Tmem97 versus >50 other proteins, including 5-HT receptors.
UKH-1114 relieves spared nerve injury-induced mechanical hypersensitivity without producing any motor impairment.

Physicochemical Properties

M.Wt	75.435
Formula	C22H24F3NO
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(9-(4-(trifluoromethyl)phenyl)-3,4,5,6-tetrahydro-1,6-methanobenzo[c]azocin-2(1H)-yl)propan-1-ol

References

1. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811.

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UKH-1114 (UKH 1114, UKH1114)

Biological Activity

Physicochemical Properties

References

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