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UKH-1114

Chemical Structure : UKH-1114

CAS No.: 2113664-14-3

UKH-1114 (UKH 1114;UKH1114)

Catalog No.: PC-61104Not For Human Use, Lab Use Only.

UKH-1114 (UKH1114) is a potent, sigma 2 receptor/Tmem97 agonist with Ki of 46 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UKH-1114 (UKH1114) is a potent, selective sigma 2 receptor/Tmem97  agonist  with Ki of 46 nM.
    UKH-1114 displays high selectivity for σ2R/Tmem97 versus >50 other proteins, including 5-HT receptors.
    UKH-1114 relieves spared nerve injury-induced mechanical hypersensitivity without producing any motor impairment.

    Physicochemical Properties

    M.Wt 75.435
    Formula C22H24F3NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-(9-(4-(trifluoromethyl)phenyl)-3,4,5,6-tetrahydro-1,6-methanobenzo[c]azocin-2(1H)-yl)propan-1-ol

    References

    1. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811.

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