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ULK-100

Chemical Structure : ULK-100

CAS No.: 945377-65-1

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ULK-100 (ULK100)

Catalog No.: PC-35708Not For Human Use, Lab Use Only.

ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM。
    ULK-100 reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=83 nM), which is more potent than SBI-0206965 showing a cellular EC50 of 2.4 uM。
    ULK-100 displays desirable kinome selectivity profile.

    Physicochemical Properties

    M.Wt 571.66
    Formula C29H32F3N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2-yl)thiophene-2-carboxamide

    References

    1. Martin KR, et al. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012.

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