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Chemical Structure : UM-164
CAS No.: 903564-48-7
Catalog No.: PC-63476Not For Human Use, Lab Use Only.
UM-164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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UM-164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β.
UM-164 inhibits c-Src autophosphorylation in TNBC cell lines, and shows potent antiproliferative activity with mean GI50 of 160 nM, alters the cell localization of c-Src in TNBC cells.
UM-164 completely inhibits p38 MAPK phosphorylation in SUM 149 cells at 50 nM.
UM-164 demonstrates potent anti-TNBC activity in xenograft models with limited in vivo toxicity.
| M.Wt | 640.686 | |
| Formula | C30H31F3N8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-5-thiazolecarboxamide |
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1. Gilani RA, et al. Clin Cancer Res. 2016 Oct 15;22(20):5087-5096.
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