UM-164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β.
UM-164 inhibits c-Src autophosphorylation in TNBC cell lines, and shows potent antiproliferative activity with mean GI50 of 160 nM, alters the cell localization of c-Src in TNBC cells.
UM-164 completely inhibits p38 MAPK phosphorylation in SUM 149 cells at 50 nM.
UM-164 demonstrates potent anti-TNBC activity in xenograft models with limited in vivo toxicity.
