Chemical Structure : UM-200
CAS No.:
UM-200
(UM200)
Catalog No.: PC-26425Not For Human Use, Lab Use Only.
UM-200 is a specific small molecule inhibitor of cGAS-STING pathway with EC50 of 1.1 uM in THP1-Dual cells that overexpress wild-type STING, blocks STING oligomerization, inhibits STING activation and signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UM-200 is a specific small molecule inhibitor of cGAS-STING pathway with EC50 of 1.1 uM in THP1-Dual cells that overexpress wild-type STING, blocks STING oligomerization, inhibits STING activation and signaling.
UM-200 inhibits STING activation via the covalent modification of C292 or C309, but not C91.
UM-200 (0.2-1 uM) inhibited the diABZI induced transcription of the IFNβ and IL6 genes in mouse macrophages. (2.5 uM) blocks the STING-dependent induction of IFNβ secretion in primary human CD14+ monocytes.
UM-200 also inhibited the diABZI induced phosphorylation of TBK1 and IRF3 in iBMBMs.
Physicochemical Properties
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M.Wt
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443.53
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Formula
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C24H21N5O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(1-(1-methyl-1H-benzo[d]imidazol-2-yl)-3-propiolamidopropyl)-2-phenylthiazole-5-carboxamide
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References
1. Barasa L, et al. J Med Chem. 2026 Mar 23. doi: 10.1021/acs.jmedchem.6c00237.
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