You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-Bcl-2-UMI-77
UMI-77

Chemical Structure : UMI-77

CAS No.: 518303-20-3

UMI-77 (UMI77)

Catalog No.: PC-45490Not For Human Use, Lab Use Only.

UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM.

Packing Price Stock Quantity
5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM.
UMI-77 displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2.
UMI-77 inhibits cell growth and induces apoptosis in pancreatic cancer cells.
UMI-77 blocks the heterodimerization of Mcl-1/Bax and Mcl-1/Bak in cells; inhibits tumor growth in BxPC-3 xenograft model.

Physicochemical Properties

M.Wt 468.3415
Formula C18H14BrNO5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-

References

1. Abulwerdi F, et al. Mol Cancer Ther. 2014 Mar;13(3):565-75.

2. Mohammad RM, et al. Semin Cancer Biol. 2015 Dec;35 Suppl:S78-103.

3. Korfi K, et al. Cell Death Dis. 2016 Apr 7;7:e2177.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: