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Chemical Structure : UMI-77
CAS No.: 518303-20-3
Catalog No.: PC-45490Not For Human Use, Lab Use Only.
UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM.
UMI-77 displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2.
UMI-77 inhibits cell growth and induces apoptosis in pancreatic cancer cells.
UMI-77 blocks the heterodimerization of Mcl-1/Bax and Mcl-1/Bak in cells; inhibits tumor growth in BxPC-3 xenograft model.
| M.Wt | 468.3415 | |
| Formula | C18H14BrNO5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- |
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1. Abulwerdi F, et al. Mol Cancer Ther. 2014 Mar;13(3):565-75.
2. Mohammad RM, et al. Semin Cancer Biol. 2015 Dec;35 Suppl:S78-103.
3. Korfi K, et al. Cell Death Dis. 2016 Apr 7;7:e2177.
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