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Chemical Structure : UMM-766
Catalog No.: PC-21831Not For Human Use, Lab Use Only.
UMM-766 is an orally available nucleoside analog with potent, broad-spectrum antiviral activity against multiple members of orthopoxviruses (EC50<1 uM against VACV).
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UMM-766 is an orally available nucleoside analog with potent, broad-spectrum antiviral activity against multiple members of orthopoxviruses (EC50<1 uM against VACV).
UMM-766 has relatively less effective against CPXV having EC50 of 2.17 and 8.09 µM in RAW and MRC5 cells, respectively.
UMM-766 (oral 10 mg/kg) protected mice against disease in the semi-lethal VACV murine model.
| M.Wt | 298.27 | |
| Formula | C12H15FN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eldrup AB, et al. 2004. Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. J Med Chem 47:5284–5297.
2. Mudhasani RR, et al. Microbiol Spectr. 2024 Feb 23:e0358623.
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