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UNC-1062

Chemical Structure : UNC-1062

CAS No.: 1350549-36-8

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UNC-1062 (UNC1062)

Catalog No.: PC-61679Not For Human Use, Lab Use Only.

UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM.
    UNC-1062 shows improved selectivity and activity against Mer relative to other TAM family RTKs (78-fold selectivity over Axl and 36-fold over Tyro3).
    UNC-1062 inhibits Mer auto-phosphorylation in human pre-B leukemia 697 cells with IC50 of 6.4 nM, also inhibits colony formation in soft agar in tumor cells.

    Physicochemical Properties

    M.Wt 514.64
    Formula C25H34N6O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[6-(Butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-cyclohexanol

    References

    1. Schlegel J, et al. J Clin Invest. 2013 May;123(5):2257-67.

    2. Liu J, et al. Eur J Med Chem. 2013 Jul;65:83-93.

    3. von Mässenhausen A, et al. Oncotarget. 2016 May 31;7(22):32678-94.

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