Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : UNC-1062
Catalog No.: PC-61679Not For Human Use, Lab Use Only.
UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM.
UNC-1062 shows improved selectivity and activity against Mer relative to other TAM family RTKs (78-fold selectivity over Axl and 36-fold over Tyro3).
UNC-1062 inhibits Mer auto-phosphorylation in human pre-B leukemia 697 cells with IC50 of 6.4 nM, also inhibits colony formation in soft agar in tumor cells.
| M.Wt | 514.64 | |
| Formula | C25H34N6O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Schlegel J, et al. J Clin Invest. 2013 May;123(5):2257-67.
2. Liu J, et al. Eur J Med Chem. 2013 Jul;65:83-93.
3. von Mässenhausen A, et al. Oncotarget. 2016 May 31;7(22):32678-94.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
