UNC-BE4-017

Chemical Structure : UNC-BE4-017

Catalog No.: PC-21869Not For Human Use, Lab Use Only.

UNC-BE4-017 is a selective STK3 small-molecule inhibitor, also potently inhibits JAK1, JAK2, and JAK3, but not other kinases in a panel of 48 kinases.

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Biological Activity

UNC-BE4-017 is a selective STK3 small-molecule inhibitor, also potently inhibits JAK1, JAK2, and JAK3, but not other kinases in a panel of 48 kinases.
UNC-BE4-017 shows affinity to STK3 in live cells in the STK3-NanoBRET assay with IC50 of 7.6 uM.
UNC-BE4-017 inhibits prostate cancer (PC) cell proliferation.

Physicochemical Properties

M.Wt	286.38
Formula	C16H22N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-cyclopropyl-N-(3,3-dimethylbutan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

References

1. Amelia U Schirmer, et al. Mol Ther. 2022 Jan 5;30(1):485-500.

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UNC-BE4-017

Biological Activity

Physicochemical Properties

References

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