Chemical Structure : UNC10415667
Catalog No.: PC-25394Not For Human Use, Lab Use Only.
UNC10415667 is a potent, benzaldehyde containing NSD2 degrader with DC50 of 460 nM in NSD2 HiBit cells, recapitulates SCF FBXO22-dependent ubiquitination and potent degradation of NSD2.
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UNC10415667 is a potent, benzaldehyde containing NSD2 degrader with DC50 of 460 nM in NSD2 HiBit cells, recapitulates SCF-FBXO22-dependent ubiquitination and potent degradation of NSD2.
UNC10415667 is a bout 2-fold more potent than UNC8732 and UNC10088 in the same assay.
UNC10415667 is dependent on the presence of Cys326 in FBXO22.
UNC10415667 (10 µM for 6 hrs) completely degraded both the long and short form of NSD2 in HEK293T cells.
M.Wt | 628.69 | |
Formula | C37H32N4O6 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Kevin C Robertson, et al. bioRxiv [Preprint]. 2025 Aug 30:2025.08.29.673087.
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