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Chemical Structure : UNC1666
Catalog No.: PC-63225Not For Human Use, Lab Use Only.
UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.
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UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.
UNC1666 only potently inhibits TrkA (IC50=0.57 uM) in a comprehensive protein kinase profiling panel, inhibits Tyro-3 and Axl with IC50 of 29 nM and 37 nM (>30-fold selectivity).
UNC1666 reduced Mer and Flt3 phosphorylation in Flt3-ITD cell lines, inhibits Erk1/2, Akt and Stat6 phosphorylation in Mer expressing cell lines.
UNC1666 reduces Mer and Flt3-mediated anti-apoptotic and pro-survival signaling, induces apoptosis in AML cells.
| M.Wt | 513.657 | |
| Formula | C26H35N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee-Sherick AB, et al. Oncotarget. 2015 Mar 30;6(9):6722-36.
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