UNC1666 |CAS:1429882-12-1 Probechem Biochemicals

Chemical Structure : UNC1666

UNC1666 (UNC 1666)

Catalog No.: PC-63225Not For Human Use, Lab Use Only.

UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.
UNC1666 only potently inhibits TrkA (IC50=0.57 uM) in a comprehensive protein kinase profiling panel, inhibits Tyro-3 and Axl with IC50 of 29 nM and 37 nM (>30-fold selectivity).
UNC1666 reduced Mer and Flt3 phosphorylation in Flt3-ITD cell lines, inhibits Erk1/2, Akt and Stat6 phosphorylation in Mer expressing cell lines.
UNC1666 reduces Mer and Flt3-mediated anti-apoptotic and pro-survival signaling, induces apoptosis in AML cells.

Physicochemical Properties

M.Wt	513.657
Formula	C26H35N5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-4-(2-(butylamino)-5-(4-(morpholinosulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

References

1. Lee-Sherick AB, et al. Oncotarget. 2015 Mar 30;6(9):6722-36.

UNC1666 (UNC 1666)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.