UNC1666 |CAS:1429882-12-1 Probechem Biochemicals

Chemical Structure : UNC1666

UNC1666 (UNC 1666)

Catalog No.: PC-63225Not For Human Use, Lab Use Only.

UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.

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Biological Activity

UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.
UNC1666 only potently inhibits TrkA (IC50=0.57 uM) in a comprehensive protein kinase profiling panel, inhibits Tyro-3 and Axl with IC50 of 29 nM and 37 nM (>30-fold selectivity).
UNC1666 reduced Mer and Flt3 phosphorylation in Flt3-ITD cell lines, inhibits Erk1/2, Akt and Stat6 phosphorylation in Mer expressing cell lines.
UNC1666 reduces Mer and Flt3-mediated anti-apoptotic and pro-survival signaling, induces apoptosis in AML cells.

Physicochemical Properties

M.Wt	513.657
Formula	C26H35N5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-4-(2-(butylamino)-5-(4-(morpholinosulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

References

1. Lee-Sherick AB, et al. Oncotarget. 2015 Mar 30;6(9):6722-36.

UNC1666 (UNC 1666)

Biological Activity

Physicochemical Properties

References

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