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Chemical Structure : UNC2025
CAS No.: 1429881-91-3
Catalog No.: PC-42993Not For Human Use, Lab Use Only.
UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer.
UNC2025 also potently inhibits Axl and Tyro3 (IC50=14 and 17 nM) in vitro.
UNC2025 inhibits Mer phosphorylation (IC50=2.7 nM) in 697 B-ALL cells, decreases phosphorylation of Flt3 (IC50=14 nM) in Flt3-ITD positive Molm-14 AML cells.
UNC2025 effectively inhibits phosphorylation of Axl (IC50=122 nM) and Tyro3 (IC50=301 nM), 40- to 100-fold selectivity for Mer over Axl and Tyro3.
UNC2025 inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.
| M.Wt | 476.6568 | |
| Formula | C28H40N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 33.33 mg/mL; H2O: < 4.9 mg/mL |
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| Chemical Name/SMILES |
Cyclohexanol, 4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans- |
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1. Zhang W, et al. J Med Chem. 2014 Aug 28;57(16):7031-41.
2. Cummings CT, et al. Mol Cancer Ther. 2015 Sep;14(9):2014-22.
3. DeRyckere D, et al. Clin Cancer Res. 2017 Mar 15;23(6):1481-1492.
4. Branchford BR, et al. J Thromb Haemost. 2018 Feb;16(2):352-363.
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