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Chemical Structure : UNC2025 hydrochloride
CAS No.:
Catalog No.: PC-42994Not For Human Use, Lab Use Only.
UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $578 | In stock | |
| 250 mg | Get quote |
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UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer; also potently inhibits Axl and Tyro3 (IC50=14 and 17 nM) in vitro; inhibits Mer phosphorylation (IC50=2.7 nM) in 697 B-ALL cells, decreases phosphorylation of Flt3 (IC50=14 nM) in Flt3-ITD positive Molm-14 AML cells, effectively inhibits phosphorylation of Axl (IC50=122 nM) and Tyro3 (IC50=301 nM), 40- to 100-fold selectivity for Mer over Axl and Tyro3; inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.
| M.Wt | 513.1177 | |
| Formula | C28H41ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.66 mg/mL (Need ultrasonic); in vivo: dissolved in DMSO and then diluted with water (DMSO:water=1:6) |
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| Chemical Name/SMILES |
Cyclohexanol, 4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-, hydrochloride |
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1. Zhang W, et al. J Med Chem. 2014 Aug 28;57(16):7031-41.
2. Cummings CT, et al. Mol Cancer Ther. 2015 Sep;14(9):2014-22.
3. DeRyckere D, et al. Clin Cancer Res. 2017 Mar 15;23(6):1481-1492.
4. Branchford BR, et al. J Thromb Haemost. 2018 Feb;16(2):352-363.
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