Chemical Structure : UNC2250
CAS No.: 1493694-70-4
Catalog No.: PC-72371Not For Human Use, Lab Use Only.
UNC2250 is a potent, selective Mer inhibitor with IC50 of 1.7 nM, displays >100-fold selectivity over Axland Tyro3.
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UNC2250 is a potent, selective Mer inhibitor with IC50 of 1.7 nM, displays >100-fold selectivity over Axland Tyro3.
UNC2250 inhibits Mer phosphorylation in 697 B-ALL cells with IC50 of 9.8 nM.
UNC2250 inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines.
UNC2250 also displays high selectivity on a broad survey of kinase families.
M.Wt | 440.592 | |
Formula | C24H36N6O2 | |
Appearance | Solid | |
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1. Zhang W, et al. J Med Chem. 2013 Dec 12;56(23):9683-92.
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