Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : UNC2250
CAS No.: 1493694-70-4
Catalog No.: PC-72371Not For Human Use, Lab Use Only.
UNC2250 is a potent, selective Mer tyrosine kinase (MerTK) inhibitor with IC50 of 1.7 nM, displays >100-fold selectivity over Axland Tyro3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | $438 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
UNC2250 is a potent, selective Mer tyrosine kinase (MerTK) inhibitor with IC50 of 1.7 nM, displays >100-fold selectivity over Axland Tyro3.
UNC2250 inhibits Mer phosphorylation in 697 B-ALL cells with IC50 of 9.8 nM.
UNC2250 inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines.
UNC2250 also displays high selectivity on a broad survey of kinase families.
| M.Wt | 440.592 | |
| Formula | C24H36N6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexan-1-ol |
|
1. Zhang W, et al. J Med Chem. 2013 Dec 12;56(23):9683-92.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
