UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3.
UNC2881 inhibits endogenous Mer tyrosine kinase activation in acute lymphoblastic leukemia cells with IC50 of 22 nM.
UNC2881 inhibits ligand-stimulated activation of a chimeric protein consisting of the extracellular domain from EGFR and the intracellular domain of Mer.
UNC2881 (3 uM) inhibits collagen-stimulated platelet aggregation in human platelet-rich plasma.
