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Chemical Structure : UNC2881
CAS No.: 1493764-08-1
Catalog No.: PC-20335Not For Human Use, Lab Use Only.
UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3.
UNC2881 inhibits endogenous Mer tyrosine kinase activation in acute lymphoblastic leukemia cells with IC50 of 22 nM.
UNC2881 inhibits ligand-stimulated activation of a chimeric protein consisting of the extracellular domain from EGFR and the intracellular domain of Mer.
UNC2881 (3 uM) inhibits collagen-stimulated platelet aggregation in human platelet-rich plasma.
| M.Wt | 463.59 | |
| Formula | C25H33N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide |
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1. Weihe Zhang, et al. J Med Chem. 2013 Dec 12;56(23):9693-700.
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