Chemical Structure : UNC3810A
CAS No.:
1818233-86-1
UNC3810A
(UNC-3810A, UNC3810)
Catalog No.: PC-24219Not For Human Use, Lab Use Only.
UNC3810A (UNC3810) is a potent, selective Tyro3 kinase inhibitor of IC50 of 1.2 nM, >10-fold selectivity versus all other kinases beyond MerTK, the most closely related TAM member, and TRKA.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UNC3810A (UNC3810) is a potent, selective Tyro3 kinase inhibitor of IC50 of 1.2 nM, >10-fold selectivity versus all other kinases beyond MerTK, the most closely related TAM member, and TRKA.
UNC3810A induces dose-dependent decrease of Tyro3 phosphorylation and attenuates signaling through the PI3K/AKT/mTOR pathway as evidenced by decreased phosphorylation of p85 PI3K and AKT in both HT-29 and B16-F10 cells.
UNC3810A (0.5-1 uM) resulted in a significant attenuation in the formation of colonies for the primary effusion lymphoma (PEL) lines, but not in other NHL subtypes where Tyro3 was not highly expressed.
UNC3810A (25 mg/kg, 3 times a week, i.p.) retards PEL tumor growth in NOD-SCID mice in a BCBL1-PEL xenograft model.
Physicochemical Properties
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M.Wt
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504.72
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Formula
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C30H44N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Cyclohexanol, 4-[2-[(2-ethylbutyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-
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References
1. Wong JP, et al. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16541-16550.
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