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Chemical Structure : UNC4203
Catalog No.: PC-35790Not For Human Use, Lab Use Only.
UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM).
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UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM).
UNC4203 display IC50 of 39 nM for FLT-3, inhibits MERTK phosphorylation in cell-based assays with IC50 of 13.8 nM.
UNC4203 inhibits MERTK phosphorylation in vivo in mice with advanced leukemia (30 mg/kg, ip injection).
| M.Wt | 504.723 | |
| Formula | C30H44N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhao J, et al. J Med Chem. 2018 Nov 5. doi: 10.1021/acs.jmedchem.8b01229.
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