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Chemical Structure : UNC569
CAS No.: 1350547-65-7
Catalog No.: PC-63226Not For Human Use, Lab Use Only.
UNC569 is a potent, small-molecule Mer kinase inhibitor with IC50 of 2.9 nM, 37 nM and 48 nM for Mer, Axl and Tyro3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 1 g | Get quote |
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UNC569 is a potent, small-molecule Mer kinase inhibitor with IC50 of 2.9 nM, 37 nM and 48 nM for Mer, Axl and Tyro3, respectively.
UNC569 decreases phosphorylated form of Merin 697 B-cell ALL (IC50=141 nM) and Jurkat T-cell ALL (IC50=190 nM) and downstream signaling through ERK1/2 and AKT, also inhibits the activation of Tyro3 (phospho-Tyro3).
UNC569 induces apoptosis in ALL cell lines (Jurkat cells, IC50=1.2 uM) and decreases colony formation.
UNC569 demonstrates potent in vivo efficacy as a single agent against T-ALL, with no apparent toxicity.
| M.Wt | 396.514 | |
| Formula | C22H29FN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-[(trans-4-Aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine |
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1. Christoph S, et al. Mol Cancer Ther. 2013 Nov;12(11):2367-77.
2. Krause S, et al. Blood. 2015 Jan 29;125(5):820-30.
3. Koda Y, et al. Anticancer Res. 2018 Jan;38(1):199-204.
4. Liu J, et al. ACS Med Chem Lett. 2012 Feb 9;3(2):129-134.
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