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UNC6587

Chemical Structure : UNC6587

CAS No.:

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UNC6587 (UNC-6587)

Catalog No.: PC-25288Not For Human Use, Lab Use Only.

UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε.

    Physicochemical Properties

    M.Wt 981.90
    Formula C45H57BrN8O12
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-((5-bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide

    References

    1. Lianxin Hu, et al. Cancer Discov. 2020 Mar;10(3):460-475.

    2. Jing Guo, et al. J Med Chem. 2025 Jun 26;68(12):12862-12880.

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