UNC6587

Chemical Structure : UNC6587

Catalog No.: PC-25288Not For Human Use, Lab Use Only.

UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε.

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Biological Activity

Physicochemical Properties

M.Wt	981.90
Formula	C45H57BrN8O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((5-bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide

References

1. Lianxin Hu, et al. Cancer Discov. 2020 Mar;10(3):460-475.

2. Jing Guo, et al. J Med Chem. 2025 Jun 26;68(12):12862-12880.

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UNC6587

Biological Activity

Physicochemical Properties

References

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