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Chemical Structure : UNC7700
Catalog No.: PC-20148Not For Human Use, Lab Use Only.
UNC7700 (UNC-7700) is a potent EED-targeted PRC2 degrader, contains a unique cis-cyclobutane linker and potently degrades all PRC2 components EED (DC50=111 nM; Dmax=84%), EZH2WT/EZH2Y641N (DC50=275 nM; Dmax=86%) and SUZ12 (Dmax=44%) in DLBCL cells.
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UNC7700 (UNC-7700) is a potent EED-targeted PRC2 degrader, contains a unique cis-cyclobutane linker and potently degrades all PRC2 components EED (DC50=111 nM; Dmax=84%), EZH2WT/EZH2Y641N (DC50=275 nM; Dmax=86%) and SUZ12 (Dmax=44%) in DLBCL cells.
UNC7700 is more potently reduces H3K27me3 levels and demonstrates a more robust anti-proliferative effect than UNC6852.
UNC7700 degrades EED approximately 15-fold more potently than UNC6852 in DB cells and can effectively degrade the core PRC2 components in DLBCL cells after 24 h (EED, DC50 = 111 nM and Dmax = 84%; EZH2WT/EZH2Y641N, DC50 = 275 nM and Dmax = 86%; and SUZ12, Dmax = 44%).
UNC7700-mediated PRC2 degradation is VHL- and proteasome-dependent.
UNC7700 decreases H3K27me3 levels and is anti-proliferative in DB cells, potently degrades all core PRC2 components.
| M.Wt | 844.99 | |
| Formula | C44H48N10O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Frances M Bashore, et al. ACS Chem Biol. 2023 Mar 6. doi: 10.1021/acschembio.2c00804.
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