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Chemical Structure : UNC8153 TFA
CAS No.: 2929304-61-8
Catalog No.: PC-22591Not For Human Use, Lab Use Only.
UNC8153 (UNC 8153) TFA is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces the cellular levels of both NSD2 protein (DC50=350 nM) and the H3K36me2 chromatin mark.
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|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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UNC8153 (UNC 8153) TFA is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces the cellular levels of both NSD2 protein (DC50=350 nM) and the H3K36me2 chromatin mark.
UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2 through a novel mechanism.
UNC8153 downregulates pathological phenotypes in multiple myeloma cells including mild antiproliferative effects in MM1.S cells containing an activating point mutation and antiadhesive effects in KMS11 cells harboring the t(4;14) translocation.
| M.Wt | 697.71 | |
| Formula | C35H38F3N5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-((4-((6-aminohexyl)carbamoyl)phenyl)carbamoyl)benzyl)-N-cyclopropyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide 2,2,2-trifluoroacetate |
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1. Ronan P Hanley, et al. J Am Chem Soc. 2023 Mar 28. doi: 10.1021/jacs.3c01421.
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