UNC8969 | Mer/Axl inhibitor | Probechem Biochemicals

Chemical Structure : UNC8969

Catalog No.: PC-23042Not For Human Use, Lab Use Only.

UNC8969 is a potent, selective, macrocyclic dual MerTK/Axl inhibitor with IC50 of 1.1/5.3 nM respectively, >12-fold selectivity over TYRO3 and FLT3.

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Biological Activity

UNC8969 is a potent, selective, macrocyclic dual MerTK/Axl inhibitor with IC50 of 1.1/5.3 nM respectively, >12-fold selectivity over TYRO3 and FLT3.

M.Wt	535.69
Formula	C29H41N7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(trans-4-((2-(Diethylamino)ethyl)carbamoyl)cyclohexyl)-34-methyl-4-oxa-2,9-diaza-1(4,2)-pyrimidina-3(1,3)-benzenacyclononaphan-6-ene-15-carboxamide

1. Kong D, et al. J Med Chem. 2024 Apr 11;67(7):5866-5882.